Anti-uroplakin III immunohistochemical staining bar = 20 µm. Inset-Neoplastic cells exhibit strong immunolabeling for uroplakin III. A–The prostatic parenchyma is replaced by multifocal to coalescing islands of neoplastic epithelial cells arranged in multiple haphazard layers with frequent individualization and formation of small cohesive clusters supported by a moderate amount of fibrovascular stroma. Photomicrographs of sections of prostate (A), liver (B), and T6 vertebral body (C and D) from the dog described in Figure 1. Within the medullary cavity of the T5 vertebral body is an area of increased firmness and opacity with white discoloration (arrowhead). There are pathological compression fractures of T2 (right arrow) and T9 (left arrow) with craniocaudal collapse of the vertebral bodies and moderate hemorrhage. Note the pale pink to tan, gelatinous material (asterisk) effacing the medullary cavity of the T6 vertebral body. Postmortem image of the vertebral column (cranial is toward the right) from an 11-year-old 13.2-kg castrated male Poodle that developed acute paraplegia after a 5-week duration of lethargy and severe signs of pain refractory to treatment.
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